Create/ login to your TRANSFAC account here Yale affiliates have free access to TRANSFAC & Proteome through the Medical Library License.

TRANSFAC is the database of eukaryotic transcription factors (and miRNAs), their experimentally determined genomic binding sites and derived DNA-binding motifs (PWMs). TRANSFAC allows to search for transcription factor targets based on experimentally determined TF-binding sites, as well as to predict putative transcription factor binding sites in regulatory regions with the included tools (Match/FMatch/CMsearch).

The PROTEOME database includes HumanPSD, with focus on gene ontology data, expression patterns and, particularly, association of human (and mouse) genes with diseases and their potential use as biomarkers, as well as TRANSPATH  on mammalian signal transduction and metabolic pathways, for functional and network analysis.

Integrated under one web interface, TRANSFAC and PROTEOME, allow seamless analysis with the included gene regulation and functional analysis tools.

This session will be focused on the following topics:

• Introduction to TRANSFAC and PROTEOME
• Analysis of single promoters for putative transcription factor binding sites
• Analysis of co-regulated genes for enriched/common transcription factor binding sites
• Upstream analysis (integrated promoter–pathway analysis) using TRANSFAC and PROTEOME integrated in the geneXplain platform

Presenters: Dr. Volker Matys, and Olga Kel-Margoulis, PhD