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Mining gene-disease associations for drug identification and discovery with Open Targets

(presentation, live tutorials and hands-on)

The Open Targets consortium was founded by three global leading institutions in the fields of pharmaceuticals, bioinformatics and genomics, GSK, EMBL-EBI, the Wellcome Trust Sanger Institute, and recently joined by Biogen, the world’s oldest independent biotechnology company. The Open Targets Platform integrates comprehensive datasets from a myriad of renowned public databases, such as UniProt, ChEMBL, Ensembl, NHGRI-EBI GWAS, EuropePMC, Cancer Gene Census, among others. The platform will incorporate the newly generated data by our Experimental projects in Oncology, Immunity, Inflammation and other areas for free and open access.

The purpose of this workshop is to acquaint participants with the Open Targets consortium. We will highlight the experimental projects in the Consortium and focus on the Open Targets Platform, launched in December 2015. The trainer will introduce the tools for visualisation and interpretation of gene-disease associations for target identification or understanding of disease biology. By the end of this half-day workshop, users will be able to carry out effective searches of data, and use the web application to visualise genes, variants, ontology, pathways (and more) in the context of human disease and therapeutics.

Denise Carvalho-Silva PhD, European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI)

Denise joined EMBL-EBI’s Open Targets team in June 2016, where she delivers workshops, provides user support and creates online training materials for the Open Targets projects. Denise holds a PhD in Biochemistry from the Universidade Federal de Minas Gerais, Belo Horizonte, Brazil, and completed her postdoctoral training in Genetics at the Australian National University, Canberra, Australia. Before coming to Open Targets, she worked in Ensembl at EMBL-EBI, at the Wellcome Trust Sanger Institute as a Research Associate in Human Evolution in Chris Tyler-Smith’s group, and as a Senior Computer Biologist in the HAVANA team on the GENCODE, EUCOMM and Pig genome projects.


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Thursday, February 9, 2017
9:30am - 12:00pm
C-103 - SHM 333 Cedar St, New Haven CT 06520
Medical School
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Event Organizer

Profile photo of Rolando Garcia-Milian
Rolando Garcia-Milian